IGF-1 LR3 Facts

What is IGF-1 LR3?

IGF-1 LR3 (Long R3 Insulin-Like Growth Factor-1) is a synthetic analog of human Insulin-Like Growth Factor-1 (IGF-1). It was engineered with two structural modifications: an arginine substitution at position 3 and a 13-amino-acid extension at the N-terminus. These changes reduce its binding to IGF-binding proteins (IGFBPs), allowing it to remain active longer than native IGF-1.

Unlike natural IGF-1, IGF-1 LR3 was developed as a research compound and has not been approved as a therapeutic medication.

Basic Information

• Compound Class: Synthetic IGF-1 analog
• Length: 83 amino acids
• Naturally Occurring: No
• Primary Target: Insulin-Like Growth Factor-1 Receptor (IGF-1R)
• Key Modification: Reduced affinity for IGF-binding proteins (IGFBPs)
• Research Focus:
  • Cell growth
  • Tissue repair
  • Muscle biology
  • Metabolic signaling
  • Growth factor signaling

Mechanism of Action

IGF-1 LR3 binds to the IGF-1 receptor (IGF-1R), activating intracellular signaling pathways involved in cellular growth, survival, and metabolism.

Researchers have found that activation of IGF-1R influences pathways such as:

• PI3K/Akt
• mTOR
• MAPK/ERK

Because IGF-1 LR3 binds less readily to IGF-binding proteins than native IGF-1, a larger fraction remains biologically available, resulting in a longer duration of receptor activation.

Areas of Research

Muscle Biology

Researchers have investigated IGF-1 LR3 for its potential effects on:

• Muscle cell proliferation
• Protein synthesis
• Satellite cell activation
• Skeletal muscle growth signaling

Most of this evidence comes from laboratory and animal research.

Tissue Repair

Research has explored IGF-1 LR3 for its role in:

• Connective tissue biology
• Cellular regeneration
• Wound healing models
• Musculoskeletal tissue repair

These findings remain primarily preclinical.

Metabolic Research

IGF-1 signaling is involved in several metabolic processes.

Researchers have investigated IGF-1 LR3 in relation to:

• Glucose metabolism
• Nutrient signaling
• Cellular energy regulation
• Insulin-related signaling pathways

Additional research is needed to better understand these effects in humans.

Cell Growth Research

IGF-1 LR3 is commonly used in laboratory research involving:

• Cell proliferation
• Cell differentiation
• Growth factor signaling
• Tissue engineering

Its extended activity makes it useful for studying IGF-1 receptor biology.

Research Use Only: This product is intended exclusively for laboratory and scientific research by qualified professionals. It is not intended for human or veterinary use, diagnosis, treatment, cure, or prevention of any disease. This product has not been evaluated or approved by the U.S. Food and Drug Administration (FDA). Handle and store in accordance with applicable laboratory safety procedures.